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Flavay™
has been successfully used for controlling hay fever and
allergies
for many decades in Europe and is now available in the
United States as a dietary supplement...
Flavay™ has been successfully
used for controlling hay fever and allergies for many decades in
Europe and is now available
in the United States as a dietary supplement. Research now shows
several ways that Flavay™ may influence the immune response to
help normalize the balance of chemicals in the body that control
inflammation and allergies.
What
are Allergies?
An
allergic reaction is a process of inflammation caused by
a disorder of the immune system.
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An allergic reaction is a process
of inflammation caused by a disorder of the immune system. The
body comes in contact with a substance (an allergen) that it
perceives as harmful—even though it is harmless. The body
releases histamine in an attempt to fight the allergen and it is
the histamine that triggers the symptoms common to allergies:
inflammation, sneezing, runny nose and itchy eyes.
Flavay™
Naturally Inhibits the Release
and Synthesis of Histamine
Flavay™
inhibits the release and synthesis of histamine—a key
factor in the promotion of inflammation.
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Research demonstrates that Flavay™
inhibits the release and synthesis of histamine (which produces
accelerated blood flow, dilates capillaries and increases their
permeability, thereby leaking plasma into surrounding tissue), a
key factor in the promotion of inflammation. Studies demonstrate
that the anti-histamine action of Flavay™ is obtained through
inhibiting the activity of the enzyme histidine decarboxylase.
Studies show that Flavay™ may lower the production of histamine
with as much as 86% inhibition of histidine decarboxylase.
This action is mediated through
the free-radical scavenging property of Flavay™.
Free
Radicals: Both Foe and Friend
When the body fights off an
allergen, the immune system's cytokines go to work, sending
messages to the brain that cause more white blood cells to
mobilize. The more white blood cells your body activates, the more
free radicals they produce, like pellets of poison, that go to
work to destroy invaders by breaking down the genetic material of
bacteria, toxins, and viruses.
When functioning properly, the
immune system is capable of identifying foreign invaders such as
viruses and bacteria and our immune components do not turn against
our own body's cells. Unfortunately, however, free radicals can
interfere with the biological components of our healthy cells in
the same way they destroy invaders, literally dismantling the
body's essential cellular proteins, fatty cell membranes and DNA.
In
allergic reactions and asthma, the body's specialized
antioxidant mechanisms fail.
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The most important natural
defenses we have against free radical damage are our body's
natural "antioxidants," a broad range of chemical
substances that all have one thing in common: they ward off free
radical damage to cells. However, in allergic reactions and
asthma, the body's specialized antioxidant mechanisms fail. The
cause of the failure might be genetic, environmental, or even
dietary, but the consequences are the same: unchecked free radical
activity.
Nitric
Oxide Toxicity, Chronic Inflammation and Asthma
Contemporary
studies of asthma and other inflammatory disorders have
all demonstrated elevated levels of nitric oxide
synthesis.
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Contemporary research shows that
elevated levels of the free radical, nitric oxide (sometimes
referred to as "NO"), appear to contribute to a number
of seemingly different disorders that all have a common element of
abnormal immune or inflammatory responses.
Studies of asthma and other
inflammatory disorders have all demonstrated elevated levels of
nitric oxide synthesis. Asthmatics exhale significantly higher
levels of nitric oxide and type II nitric oxide synthase (also
known as "NOS") expression is increased in biopsy
specimens from asthmatics.
Flavay™ can significantly
scavenge nitric oxide radicals. However, as we'll discuss next,
your body needs a certain amount of nitric oxide in order to
maintain good health. Nitric oxide is paradoxical. It can both
mediate normal physiological functions and it can be highly toxic.
Flavay™
can help regulate a healthy balance of nitric oxide
in the body.
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Nitric oxide can act as an
anti-inflammatory under normal health conditions, but it can have
the opposite effect and cause more inflammation to an already
inflamed area when overproduced. The key, therefore, is to
maintain the optimum balance of this double-edged sword,
nitric oxide.
Flavay™
Scavenges the Body's Terrorists:
Rampaging Free Radicals
Free radicals are like pellets of
poison that destroy invaders by interfering with their cellular
machinery, literally dissolving or breaking down the genetic
material of bacteria, toxins and viruses.
When all is going well, the
immune system is capable of identifying foreign invaders such as
viruses and bacteria by accurately "reading" molecular
codes found on cell surfaces. These molecular codes are like flags
of different armies, and the immune system will not attack a cells
if it "reads" a flag belonging to the body's own host
army. Unfortunately, however, free radicals can interfere with the
biological components of our healthy cells, just as they destroy
invaders. This leads to many diseases.
When the immune system's
cytokines activate macrophages (the white blood cells capable of
gobbling up invading viruses and bacteria), the macrophages
produce large amounts of nitric oxide in the course of battle.
Nitric oxide is a colorless gas produced by many different cells
in the body that, depending on the situation, can be very
good or very bad. Nitric oxide plays several important
roles in the body:
- Nitric oxide is an important
signaling molecule that turns genes on and off.
- By controlling the muscular
tone of blood vessels, nitric oxide regulates the
circulation and normalizes blood flow.
- Nitric oxide modulates
communication between brain cells and is instrumental in
helping us concentrate and learn new information, and also
in maintaining memory.
- When produced by immune
cells, nitric oxide fights infection, kills tumor cells and
promotes wound healing.
- Nitric oxide is essential
for perceiving pleasure and pain, and it helps translate
sexual excitement into penile erections.
- Nitric oxide aids in
digestion of food by helping to control gastric movements.
But nitric oxide can be very
destructive under other circumstances:
- Nitric oxide restricts blood
flow.
- When produced in excess by
immune cells, nitric oxide can trigger chronic inflammation,
which can cause asthma, arthritis, colitis, inflammatory
bowel disease and possibly cancer.
- Nitric oxide promotes
production of more free radicals.
- In the brain, nitric oxide
can hamper mental function and cause memory loss and brain
aging.
The real trouble starts when
nitric oxide encounters the superoxide free radical and becomes
peroxynitrate, which destroys antioxidants like glutathione,
vitamin E and common flavonoids, and damages proteins in the body.
The good news is that Flavay™ scavenges peroxynitrate and has a
remarkable modulatory effect on nitric oxide—helping to maintain
optimal levels in the body and neutralizing this free radical
where it does harm.
Superior
Antioxidant Support
Flavay™ is superior to other
antioxidants because its protective effects are multiplied in the
body. While it provides its own, powerful antioxidant protection,
it also supports the dynamic interplay between other antioxidants
in the body. Flavay's ability to “recycle,” or regenerate
vitamins C and E after they have quenched free radicals vastly
extends their unique antioxidant powers, helping to maintain an
optimal, synergistic antioxidant balance in the body.
Flavay™ is rapidly absorbed and
very quickly distributed throughout the body. As a free radical
fighter, Flavay™ comes to the aid of the body more quickly than
other antioxidants, reducing the potential for free radical damage
and the ravages of aging. Flavay™ also possesses more reactive
sites for neutralizing free radicals than other known
antioxidants. Furthermore, Flavay™ permits reactivity with both
positively and negatively charged free radical species. What this
means is that Flavay™ can “quench” or “scavenge”
(neutralize) a broad variety of free radicals. Highly reactive as
an antioxidant in both lipid (fat) and aqueous (water) phases,
Flavay™ neutralizes oxygen free radicals and is a valuable
protector of healthy cells in a variety of internal conditions.
This is a unique property among antioxidants, as most work either
in lipid or aqueous phases, but not both. As a free radical
scavenger, Flavay™ is like an antioxidant prize fighter that can
successfully take on all challengers, big or small, in any kind of
weather.
"Radical
Scavenger Effect" of Flavay™
Protected by U.S. Patent No. 4,698,360
Flavay™ is a strong antioxidant
that is patented as a scavenger of the free radicals that
play a major role in the initiation, duration and breakdown of
inflammation.
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"[A]
method for preventing and fighting the harmful
biological effects of free radicals in the
organism of warm blooded animals and more especially human
beings, namely cerebral involution, hypoxia
following atherosclerosis, cardiac or cerebral infarction,
tumour promotion, inflammation, ischaemia,
alterations of the synovial liquid, collagen
degradation, among others. The method consists in
administering to said animals and especially to human
beings an amount, efficient against said effects, of a
plant extract with a proanthocyanidins content which has a
radical scavenger effect"—Dr. Jack
Masquelier, U.S. Patent No. 4,698,360.
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Flavay™
is the product—used in the actual experiments—by
which Dr. Jack Masquelier established and patented the "Radical
Scavenger Effect."
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This means that your immune
system works better at controlling inflammations and
allergies—all because of Flavay™.
CLICK HERE TO SEE WHAT THE CUSTOMERS ARE SAYING
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All About Flavay
| Flavay Plus | What Does
it Do? | Proven Safety
| Directions for Use
Q&A | Comparative Analysis | Endorsements & Testimonials
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HealthyBodynMind
1-877-352-8042 • (306) 352-8042 • info@healthybodynmind.com
Protected by U.S. PATENT NO. 4,698,360 and international
patents.
Copyright © 1995-2004 Healthy Publisher.
All rights reserved. Healthy Source LLC
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Statements made herein have not been
evaluated by the Food and Drug Administration. These products are
not intended
to diagnose, treat, cure or prevent any disease.
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REFERENCES:
Top  |
Masquelier, J. Plant extract with
a proanthocyanidins content as a therapeutic agent having radical scavenging
effect and use thereof. U.S. Patent No. 4,698,360, 1987.
Masquelier, J. A lifetime devoted to OPC and
Pycnogenols. Alfa Omega
Editrice,
Pub., 1996.
Schwitters, B.,
Masquelier, J. OPC in practice. Alfa Omega
Editrice, Publishers,
1995.
Lombard, J., Germano, C. The brain wellness plan: breakthrough medical,
nutritional and immune-boosting therapies to prevent and treat: depression,
Alzheimer's disease, chronic fatigue syndrome, attention deficit disorder,
multiple sclerosis, Parkinson's disease, Lou Gehrig's disease. Kensington
Pub. Corp., 1998.
Kilham, C., Masquelier, J.
OPC: The miracle antioxidant. Keats Publishing,
Inc., 1997.
Packer, L., et al. The antioxidant miracle: your complete plan. John Wiley
& Sons, Inc., 1999.
Packer, L., et al. Antioxidant food supplements in human health. Academic
Press, 1999.
Lincoln, J., Hoyle, C.H.V., Burnstock, G., Nitric oxide in health and disease.
Cambridge University Press, 1997.
Moncada, S., Nistico, G.,
Bagetta, G., Higgs,
E.A. Nitric oxide and the
cell. Princeton University Press, 1998.
Facino, R.M., et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Passwater, R.A. The antioxidants: the nutrients that guard your body. Keats
Publishing, Inc., 1985.
Barilla, J. et al. The nutrition superbook: volume 1: the antioxidants.
Keats Publishing, Inc., 1995.
Facino RM, et al. Free radical scavenging action and anti-enzyme activities
of procyanidines from Vitis vinifera. A mechanism for their capillary protective
action. Arzneimittelforschung, 44: 592-601, 1994.
Kuttan R, et al. Collagen treated with catechin becomes resistant to the
action of mammalian collagenase. Experientia, 37: 221-223, 1981.
Masquelier, J., et al. Stabilization du collagene par les oligomeres
procyanidoliques.
Acta Therapeutica, 7:101-105, 1981.
Masquelier, J. Aspects pharmacologiques nouveaux de certains
flavonoides.
A Vie Medical 12:1969.
Laparra, J., et al. Etude pharmaco-cinetique des oligomers procyandoliques
totaux du raisin. Acta Therapeutica, 4, 1978.
Laparra, J., et al. Etude pharmacocinetique des oligomeres
flavonoliques.
Plantes med et phyto, Tome XI, pp. 133-142, 1977.
Robert A.M.; Groult, N.; Six, C.; Robert, L. Etude de l’action des
oligomeres procyanidoliques sur des cellules mesenchymateuses en culture.
Ii l’attachment des fibres elastiques aux cellules. (Study of the effect
of procyanidolic oligomers on mesenchymal cells in culture. Ii attachment
of elastic fibers to the cells.) Pat Biol, (30)6:601-7, 1990.
Porter, Lawrence J., Wong Rosalind Y. Chan, Bock G. The molecular and crystal
structure of (+)-2,3-trans-3,4-trans-leucocyanidin [(2r,3s,+r)-(+)-3,3’,
4.4’, 5.7’-Hexahydroxyflavan] dihydrate, and comparison of its
heterocyclic ring conformation in solution and the solid state. Journal
of the Chemical Society; Perkin Transactions I 1985. pp. 1413-17.
Masquelier, J. Proanthocyanidins et radicaux
libres. 1985.
Uchida, S., et al. Condensed tannins scavenge active oxygen free radicals.
Med Sci Res, (15) 1987. pp. 831-832.
Ariga, T. Radical scavenging action and its mode in procyanidins b-1 and
b-3 from azuki beans to peroxyl radicals. Agric Biol Chem, 54(10) 1990.
pp. 2499-2504.
Da Silva, R., et. al. Radical scavenger capacity of different procyanidins
from grape seeds. Presented at a symposium, “Free radicals in biotechnology
and medicine.” Royal Society Of Chemistry, London January 1990, pp.
79-80.
Bauman, J., Wurm, G., Bruchhausen, F. “Hemmung der prostagladinsynthetase
durch flavonoide und phenolderivate im vergleich nit deren 02 radikalfangereigenschaften”
Arch Pharm, (Weinheim) 313 (1980) pp. 330-337.
Lombard, J., et al. The brain wellness plan. Kensington Pub. Corp., 1998.
Flesch M., et al., Effects of red and white wine on endothelium-dependent
vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 1998;275:1183-94.
Fitzpatrick, D.F., Fleming R.C., Bing B, Maggi DA, O'Malley RM. Isolation
and characterization of endothelium-dependent vasorelaxing compounds from
grape seeds. J Agr & Food Chem In press.
Fitzpatrick, D.F., Maggi D, Bing B, Coffey RG. Vasorelaxation, endothelium,
and wine. BioFactors 1997;6:455-459.
Fitzpatrick, D.F., Hirschfield SL, Ricci T, Jantzen P, Coffey RG. Endothelium-dependent
vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol
1995;26:90-95.
Fitzpatrick, D.F., Hirschfield SL, Coffey RG. Endothelium-dependent vasorelaxing
activity of wine and other grape products. Amer J Physiol 1993;265:H774-H778.
Kuttan, R., Donnelly,
P.V., Di Ferrante, N. Collagen treated with catechin
becomes resistant to the action of mammalian collagenase. Experientia, 37:
221-223, 1981.
Masquelier, J. Procyanidolic
oligomers. J Parums Cosm
Arom, 95: 89-97, 1990.
Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding
of pycnogenols to elastin affects its rate of degradation by elastases.
Biochem Pharmacol, 33: 3933-3939, 1984.
Kakegawa, H., et al. Chem.
Pharm. Bull. 33:5079, 1985.
Harmand, M.F.,
Blanquet, P. The fate of total flavanolic oligomers extracted
from ‘vitus vinifera l.’ in the rat. European Journal of Drug
Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30.
Delrieu, P., Ding J.,
Escande, B., Samain, D. Free-radical scavenging activity
of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo
and in vitro study. Cosmetology Department & S Biovectors, Ramonville
St. Agne France. pp. 1-9.
Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting
enzyme by flavanolic compounds: in vitro and in vivo studies. Planta
Medica,
May 26, 1986. pp. 12-15.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez l’animal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40.
Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques
chez l’animal-activite aniagoniste vis-a-vis des mediateurs de l’inflamation.
Sanofi Res Toul Cedex Fr, pp. 31-40.
Dubos, C., Durst, G.,
Hugonot, H. Evolution de la resistance
capillaire,
spontanement ou artificiellement diminuee par l’action d’une substance
capillaro-toxique chez des personnes agees--action benefique d’un agnet
actif sur la micro-circulation: l’Endotelon. Inform. Therapeut. 1980.
pp. 302-305.
Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude d’un
microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990.
Lagrue, G., Olivier-Martin, F.,
Grillot, A. “Etude des effets des oligomeres
du procyanidol sur las resistance capillaire dand l’hypertension arterielle
et certaines nephropathies.” Sen. Hosp. Paris 18-25 Septembre, 1981.
Beylot, C., Bioulac, P. Essai therapeutique d’un angioprotecteur
peripherique,
l’Endotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24,
1980.
Lesbre, F.X., Tigaud, J.D. Effect de l’Endotelon sur l’indice
de fragilite capillaire dan une population specifique: les sujets
cirrhotiques. Gaz. Med. de France, (90)24 1983.
Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs
par un microangioprotecteur l’Endotelon. Bordeaux Med, 11:685-8, 1981.
Delacroix, P. Etude en double aveugle de l’Endotelon dans l’insuffisance
veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981.
pp. 1793-1802.
Thebaut, J.F, Thebaut, P.,
Vin, F. Etude de l’Endotelon dand les manifestations
fonctionnelles de l’insuffisance veineuse peripherique-resultats d’une
etude en double aveugle portant sur 92 patients.” Gazette Medicale,
(92)1, 1985. pp. 96-100.
Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate
metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty
Acids, 38:181-8, 1989.
Masquelier, J.
Pycnogenols: recent advances in the therapeutical activity
of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant
Research and Journal of Natural Products, July 1980 pp. 243-256.
Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications
in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106.
Masquelier, J. “Les procyanidols du vin leur role dans l’alcoolisme.”
pp. 88-93.
Gazave, J.M. “Notions recentes sur les capillaires”
unpub. bulletin
from the Laboratoire De Physiologie Patholigie pp. 26-29.
Ruf, J.C. Wine and polyphenols related to platelet aggregation and
atherothrombosis.
Office International Vigne et du Vin, Nutrition and Health Unit, Paris France;
Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131),
1999.
Blaszo, G. Gabor, M.
Oedema-inhibiting effect of
procyanidin. Acta Physiologica
Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980.
Tayau, M.F, LeFevre, G. Action du leucocyanidol sur l’hyalaluronidase.
Bull Soc Pharm Bordeaux, 95:132-136, 1956.
Lamy, M. Utilization des oligomeres procyanidoliques en
gynecologie. Essai
Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22.
Henriet, J.P “Une Etude Exemplaire Pour Un
Phlebotrope: l’etude
EIVE.’ Unpub., pp. 77-83.
Pfister, A., Simon,
M.T., Gazave, J.M. Sites de fixation des oligomeres
procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye.
Acta Therapeutica (8) 1982. pp. 223-237.
Kuttan, R., Donnelly, P., Di
Ferrante, N. “Collagen treated with (+)
-catechin becomes resistant to the action of mammalian
collagenase.”
Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col.
of Med., Houston TX. 28, May, 1980.
Gendre, P., Laparra, J.,
Barraud, E. “Effect protecteur des oligomeres
procyanidoliques sur le lathyrisme experimental chez le rat.” Ann.
Pharm. Francaises, (43)1, 1985 pp. 61-73.
Corbe, C., Boissin, J.P.,
Siou, A. Light vision and chorioretinal circulation.
Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr.
Opthalmol,
(11)5:453-460, 1988.
Boissin, J.P., Corbe C.,
Siou, A. Chorioretinal circulation and dazzling:
use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4,
177-9, 1988.
Proto, F. et al. Electrophysical study of vitis vinifera procyanoside oligomers
effects on retinal function in myopic subjects. Ann Ott Clin Ocul, 114:85-93,
1988.
Saracco, J.B., Estachy,
G.M. Etude d l’Endotelon en
opthalmologie.
Gaz Med de France, 88:2035-2038, 1981.
Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies.
Klin Monatsbl Augenheilkd, 178:386-389, 1981.
Corbe, C., et al. Microangiopathy of the retina. J. Fr.
Opthalmol, 11:453,
1988.
Verin, M.M., Vildy, A.,
Maurin, J.F., Retinopathies et
O.P.C. Bordeaux
Medicale,
(16)11. pp. 1467-74, 1978.
Soyeux, A. et al.
Endotelon. Diabetic retinopathy and
hemorheology. Bull
Soc Ophtalmol Fr. 87(12):1441-4, 1987.
Fromantin, M. “Les oligomeres procyanidoliques dans le traitement de
la fragilite capillaire et de la retinopathie chez les diabetiques. A propos
de 26 cas.” Med Int, 16(11):432-434, Nov. 1981.
Arne, J.L. Contribution a l’etude des oligomeres procyanidoliques:
Endotelon, dans la retinopathie diabetique (a propos de 30 observations).
Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982.
Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind
study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5,
1984.
Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in
rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981.
Gabor, M. Pharmacologic effects of flavonoids on blood vessels.
Angiologica,
9:355-374, 1972.
Havsteen, B.
Flavonoids, a class of natural products of high pharmacological
potency. Biochem Pharmacol, 32:1141-48, 1983.
Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser
Verlag, Vol. 7/1, Univ. of
Marburg/Lahn, Ger., 1977.
Masquelier, J. Action protectrice du vin sur l’ulcere
gastrique. Resultats,
p. 61.
Amella, M., et al. Inhibition of mast cell histamine release by flavonoids
and bioflavonoids. Planta Medica, 5116-20, 1985.
Shaw, R. How [Australian] PycnoGenol [MASQUELIER’s®] Helps Sports
People.
Masquelier, J. Procyanidolic oligomers
(leucocyanidins). Parfums Cosmet
Arom 95:89-97, 1990.
Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques (Endotelon) dans le traitement des lymphoedemes
post-therepeutiques de members
superieurs. Symposium Satellite, Congres International d’Angiologie,
Toulouse, France, 4-7 Oct. 1989.
Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks
of intense training. Abstract submitted to national meeting of the Amer
College of Sports Medicine, June 1998.
Monteleone, P., Maj, M.,
Beinat, L., Natale, M.,
Kemali, D. Blunting by
chronic phosphatidylserine administration of the stress-induced activation
of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm
43: 385–388, 1992.
Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine
administration during two weeks of resistive exercise-induced overtraining.
Bio of Sport 15(3):135-44, 1998.
Laparra, J., Michaud, J.
Masquelier, J. Action des oligomeres procyanidoliques
sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux,
1976.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur l’oxydation
de l’acide ascorbique par les ions cuivriques. Bull. de la Societe
de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304.
Masquelier, J. Action comparee de divers facteurs vitaminiques p sur l’acide
ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4)
1951. pp.304-306
Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T.,
Nonaka, G., Mishioka,
I. “Inhibitory effects of tannins on hyaluronidase activation and on
the degranulation from rat mesentery mast cells.” Chem. Pharm. Bull.
33(11)1985. 5079-5082.
Reiman, H.J., Lorenz, M., Fischer, R.,
Frolich, H., Meyer, J. “Histamine
and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress
ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase
in vitro.” Dirkhauser Verlag,Vol. 7/1, 1977.
Pariente, J.J.
Parientl-Amsellem, J. “Les oedemes
post-traumatoqies
chez le sportif: essai controle de l’Endothelon.” Actualite Therapeutique
90(3) 2/11 1983 pp. 231-235.
Masquelier, J., et al. “Flavonoids et Pycnogenols” Int J Vit Nut
Res, (49)3:307-311, 1979.
Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol.
25(2):135-9, 1987.
Pantaleoni, G.C.,
Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica
Report, 1971.
Laparra, J., et al., Acta
Therapeutica, 4:233, 1978.
Volkner, Wolfgang Muller,
Ewald, Micronucleus assay in bone marrow cells
of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects
143010 & 143021; Feb. 1989.
Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover,
Germany, 1967-1971.
Dumon, M., Michaud, J.,
Masquelier, J. Proanthocyanidin content in vegetable
extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux,
129:51-65, 1990.
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