Chronic stress negatively impacts many of the body's functions, 
but Flavay Plus™ can help.

Chronic Stress Alters
Immune Function

Stress is interpreted by the body as a danger signal and results in the "fight or flight" response which affects both the brain and immune system.Your adrenal glands release cortisol which allows your body to defend itself through heightened awareness, increased heart rate, and increased blood flow to muscles. Cortisol also has the ability to alter the immune system's production of white blood cells, and to cause them to migrate to particular areas of the body during times of injury, infection, and stress.

However, during periods of chronic stress, continued activation of the immune system persists like the "boy who cried wolf," in that the danger signals are ignored because of their persistence.

Mobilization of Immune Cells Produces Free Radicals

Chemical messengers called "cytokines" go to work, sending messages to the brain that cause more white blood cells to mobilize. The more white blood cells your body activates, the more free radicals they produce. These free radicals are among your immune system's most powerful weapons, during periods of emotional stress and disease, in response to injury, and even in the aging process itself. Research demonstrates that Flavay™ may restore cytokine imbalances and normalize white blood cell activity, thereby normalizing immune function.

Flavay™ Scavenges the Body's Terrorists:
Rampaging Free Radicals

Free radicals are like pellets of poison that destroy invaders by interfering with their cellular machinery, literally dissolving or breaking down the genetic material of bacteria, toxins and viruses.

When all is going well, the immune system is capable of identifying foreign invaders such as viruses and bacteria by accurately "reading" molecular codes found on cell surfaces. These molecular codes are like flags of different armies, and the immune system will not attack a cells if it "reads" a flag belonging to the body's own host army. Unfortunately, however, free radicals can interfere with the biological components of our healthy cells, just as they destroy invaders. This leads to many diseases.

When the immune system's cytokines activate macrophages (the white blood cells capable of gobbling up invading viruses and bacteria), the macrophages produce large amounts of nitric oxide in the course of battle. Nitric oxide is a colorless gas produced by different cells in the body that, depending on the situation, can be very good or very bad. Research has shown that Flavay™ works to keep nitric oxide within normal limits in the body.

Chronic Stress Alters Cardiovascular Function

When we are under stress, our adrenaline flows and causes our blood vessels to constrict, increasing blood pressure, and blood platelets are activated—prepared to clump together to form a clot. This "fight or flight response" is appropriate in short-term dangerous situations. The blood platelets are prepared for an injury to more quickly form a blood clot and more efficiently prevent blood loss.

Chronic stress causes constant constriction of blood vessels and continuously "sticky" blood platelets, always prepared to form a clot. These are classic risk factors for heart disease and stroke. When blood vessels are constricted there is less area for the blood to flow through and atherosclerotic plaque may further reduce the space for blood flow. If some blood platelets stick together and form a clot, the vessel may be completely clogged and surrounding tissue is deprived of oxygen and nutrients. This is how a heart attacks and strokes develop.

Research shows that Flavay™ improves nitric oxide levels produced by cells that line the arteries. Nitric oxide controls the muscles surrounding the blood vessels and causes them to relax. At the same time, nitric oxide causes blood platelets to return to their normal, smooth condition.

Flavay™ and the Nitric Oxide Connection

Nitric oxide is a colorless gas produced by different cells in the body that, depending on the situation, can be very good or very bad. Nitric oxide plays several important roles in the body:

• Nitric oxide is an important signaling molecule that turns genes on and off.
  
• By controlling the muscular tone of blood vessels, nitric oxide regulates the circulation and normalizes blood flow.
  
• Nitric oxide modulates communication between brain cells and is instrumental in helping us concentrate and learn new information, and also in maintaining memory.
  
• When produced by immune cells, nitric oxide fights infection, kills tumor cells and promotes wound healing.
  
• Nitric oxide is essential for perceiving pleasure and pain, and it helps translate sexual excitement into penile erections.
  
• Nitric oxide aids in digestion of food by helping to control gastric movements.

But nitric oxide can be very destructive under other circumstances:

• Nitric oxide restricts blood flow.
  
• When produced in excess by immune cells, nitric oxide can trigger chronic inflammation, which can cause arthritis, colitis, inflammatory bowel disease and possibly cancer.
  
• Nitric oxide promotes production of more free radicals.
  
• In the brain, nitric oxide can hamper mental function and cause memory loss and brain aging.

The real trouble starts when nitric oxide encounters the superoxide free radical and becomes peroxynitrate, which destroys antioxidants like glutathione, vitamin E and common flavonoids, and damages proteins in the body. The good news is that Flavay™ scavenges peroxynitrate and has a remarkable modulatory effect on nitric oxide—helping to maintain optimal levels in the body and neutralizing this free radical where it does harm.

"Radical Scavenger Effect" of Flavay™
Protected by U.S. Patent No. 4,698,360

Originally patented and licensed in France for therapeutic uses, Flavay™ is the very product—used in the actual experiments—by which Dr. Jack Masquelier established and patented the "radical scavenger effect."

During any challenge to your immune system—because of disease, infections, toxic exposure, stress or aging—you need the extra antioxidant power in Flavay™ to help scavenge the free radicals naturally produced by the immune system's cells during warfare. When your immune system works better, your joints hurt less and your blood flows better.

Flavay™ Increases the Activity of Vitamins C and E

Flavay™ recycles and significantly extends the lifetime of vitamin C and potentiates vitamin E, and thereby creates a more powerful, synergistic antioxidant defense in the body. This is important because vitamins C and E are key players in the body's protective antioxidant army.

Antioxidants fight corrosive and destructive forces that constantly work to break down our bodies. Overwhelming scientific evidence demonstrates that those of us who eat a diet rich in antioxidants and take antioxidant supplements will live longer and healthier lives. Working as a defensive army, antioxidants work together in the body to maintain our health and vigor by protecting us from damage caused by rampaging free radicals which, like terrorists, injure healthy cells and tissues.

Don't underestimate the threat that free radicals pose to our health. Contemporary scientists now believe that free radicals are causal factors in nearly every known disease, from heart disease to arthritis to Parkinson's to Alzheimer's to ALS to multiple sclerosis to cataracts to the aging process itself.

As a free radical fighter, Flavay™ comes to the aid of the body more quickly than other antioxidants, reducing the potential for free radical damage and the ravages of aging. Flavay™ also possesses more reactive sites for neutralizing free radicals than other known antioxidants. Furthermore, Flavay™ permits reactivity with both positively and negatively charged free radical species. What this means is that Flavay™ can “quench” or “scavenge” (neutralize) a broad variety of free radicals. Highly reactive as an antioxidant in both lipid (fat) and aqueous (water) phases, Flavay™ neutralizes oxygen free radicals and is a valuable protector of healthy cells in a variety of internal conditions. This is a unique property among antioxidants, as most work either in lipid or aqueous phases, but not both. As a free radical scavenger, Flavay™ is like an antioxidant prize fighter that can successfully take on all challengers, big or small, in any kind of weather.

Flavay Plus™ Provides Synergistic Help
for Confronting Stress

Flavay Plus™ contains a synergistic blend of Flavay™ with antioxidant vitamins, minerals and other phytonutrients to best take advantage of the dynamic interplay among the antioxidants and their co-factor nutrients. Of particular interest is phosphatidyl serine, as research has shown that it may have the capacity to normalize the stress-induced activation of the above-described, "fight or flight response."

Phosphatidyl serine: Flavay Plus™ is formulated with phosphatidyl serine (Leci-PS™), a complex of amino and fatty acids extracted from soy lecithin, which has proven to be a safe, potentially effective therapeutic agent in treating memory deficit disorders and is an often-used supplement for attention deficit disorders. Phosphatidyl serine has been the subject of many human clinical trials regarding memory loss, mood, cognitive performance, learning ability and stress.

Phosphatidyl serine is a phospholipid that is vital to brain cell structure and function. Phospholipids are molecules containing both amino and fatty acid components, which are found in every cell membrane in our bodies. Phosphatidyl serine plays an important role in our neurotransmitter systems, in metabolism levels of the brain, and in maintaining nerve connections in the brain. It appears to help reestablish the normal down-regulation of cortisol secretion that is increased in chronically stressed individuals.

Research has shown that phosphatidyl serine works to keep the brain’s processes within normal limits, raising them when they are low and lowering them when they are high. So phosphatidyl serine boosts the weak stress response in the elderly person and calms down exaggerated stress in the healthy young person. Both physical and mental stressful conditions cause stress hormones to be released into circulation, even in the young and healthy. Phosphatidyl serine given to athletes prior to starting exercise produced an impressive degree of down-regulation of the stress hormones. Phosphatidyl serine may have the capacity to normalize the stress-induced activation of the "fight or flight response." In a double-blind, placebo-controlled study conducted in Italy, phosphatidyl serine lowered stress hormone (cortisol) production by 30 percent.

Two more recent placebo controlled studies confirmed the earlier double-blind trials; young, university students experienced significantly less stress from tests when they took phosphatidyl serine (300 mg daily for 30 days), they stayed more clear-headed and composed, and kept a more stable mood.

Flavay™: More Than 50 Years of Protection

Now available in the United States, Flavay™ is the actual polyphenol that has been licensed and sold in France for vascular benefits since 1950. And, Flavay Plus™ includes the highest-quality phosphatidyl serine and other antioxidant nutrients and their co-factors in order to offer you and your family with the best help that nutritional science has to offer for confronting the stressful challenges of living in today's world.

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